TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on November 2, 2021 - Published by Cold Spring Harbor Laboratory Press PERSPECTIVE Eukaryotic mRNA 3
 processing: a common means to different ends Gregory M. Gilmartin University of Vermont, Burlington, Vermont 05405, USA In principle, the formation of the 3 end of a eukaryotic for the evolution of two distinct 3 processing complexes mRNA is a simple process. At a minimum, it involves are likely to involve the conflicting pressures of post- the hydrolysis of a single phosphodiester bond in the transcriptional regulation: coordinate cell cycle control nascent transcript. For one unique class of mRNAs, tran- of the replication-dependent histone mRNAs versus the scripts of the metazoan replication-dependent histone developmental and cell-type-specific regulation of alter- genes, this is indeed the only requirement. All other eu- native poly(A) site selection. karyotic mRNAs require both cleavage and subsequent poly(A) addition to the newly generated 3 hydroxyl. De- spite this apparent simplicity, and more than two de- Similarities among contrasts cades of work, basic questions concerning the mecha- The RNA sequence elements that direct the 3 process- nisms of 3-end formation for both classes of transcripts ing of histone and polyadenylated mRNAs could hardly persist. The accumulated evidence indicates 
TI - Eukaryotic mRNA 3' processing: a common means to different ends
JF - Genes & Development
DO - 10.1101/gad.1378105
DA - 2005-11-01
UR - https://www.deepdyve.com/lp/unpaywall/eukaryotic-mrna-3-processing-a-common-means-to-different-ends-6eAy4Ir6Lv
DP - DeepDyve
ER -