TY - JOUR
AU - Akiyama, Tetsu
AB - Background: The Wnt/Wingless signalling pathway plays an important role in both embryonic development and tumorigenesis. β‐Catenin and Axin are positive and negative effectors of the Wnt signalling pathway, respectively. Results: We found that Axin interacts with β‐catenin and glycogen synthase kinase‐3β (GSK‐3β). Furthermore, the regulation of the G‐protein signalling (RGS) domain of Axin is associated with the colorectal tumour suppressor adenomatous polyposis coli (APC). Overexpression of Axin in the human colorectal cancer cell line SW480 induced a drastic reduction in the level of β‐catenin. Interaction with β‐catenin and GSK‐3β was required for the Axin‐mediated β‐catenin reduction. Conclusion: Axin interacts with β‐catenin, GSK‐3β and APC, and negatively regulates the Wnt signalling pathway, presumably by regulating the level of β‐catenin.
TI - Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level
JF - Genes to Cells
DO - 10.1046/j.1365-2443.1998.00198.x
DA - 1998-06-01
UR - https://www.deepdyve.com/lp/wiley/axin-an-inhibitor-of-the-wnt-signalling-pathway-interacts-with-catenin-6htfMb8PZ4
SP - 395
VL - 3
IS - 6
DP - DeepDyve
ER -