TY - JOUR
AU1 - Amato, Marco C.
AU2 - Giordano, Carla
AU3 - Galia, Massimo
AU4 - Criscimanna, Angela
AU5 - Vitabile, Salvatore
AU6 - Midiri, Massimo
AU7 - Galluzzo, Aldo
AU8 - ,
AB - OBJECTIVETo individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function.RESEARCH DESIGN AND METHODSVisceral adiposity index (VAI) was first modeled on 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio- and cerebrovascular risk factors.RESULTSAll components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (odd ratio [OR] 2.45; 95% CI 1.52–3.95; P < 0.001) and cerebrovascular (1.63; 1.06–2.50; P = 0.025) events. VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (Rs = −0.721; P < 0.001). By contrast, no correlations were found for waist circumference and BMI.CONCLUSIONSOur study suggests VAI is a valuable indicator of “visceral adipose function” and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.
TI - Visceral Adiposity Index
JF - Diabetes Care
DO - 10.2337/dc09-1825
DA - 2010-01-12
UR - https://www.deepdyve.com/lp/pubmed-central/visceral-adiposity-index-6mLuvtHTVe
SP - 920
EP - 922
VL - 33
IS - 4
DP - DeepDyve
ER -