TY - JOUR
AU - Lander, Eric S.
AB -  Human and Mouse Gene Structure: Comparative Analysis and Application to Exon Prediction Serafim Batzoglou ~'2 4, Llor Pachter 2'3, Jill Meslrov 4, 571 Bonnie t~erger-' ' and Eric S. Lander 6'7'4 ABSTRACT ';re describe a novel analyttcal approach to gene recognmon based on cross-species comparison We first undertook a comparison of orthologous genom,c Ioc~ from human and mouse, study,ng the extent of s~mllartty m the number, s~ze and sequence of exons and mtrons We then developed an approach /or recogmzmg genes within such orthologous regmns, by first ahgn,ng the reg,ons using an iteratwe global ahgnment sys!em and then ~denttfymg genes based on conservation of exonic features at ahgned pos~tions m both species The ahgnment and gene recognmon are performed by new programs called GLASS and ROSETTA, respectively R O S E T r A performed well at exact Identlficatmn of coding exons tn 117 orthologous pmrs tested. Keywords Gene Recogmtion, Global Ahgnments, Comparative Genomlcs 1. INTRODUCTION A fundamental task In analyzmg genomes is to ldenufy the genes This is relatively straightforward for orgamsms with compact genomes (such as bacteria, yeast, rims and worms), because exons tend to be large and the mtrons are rather non-existent or tend to 
TI - Human and mouse gene structure: comparative analysis and application to exon prediction
DO - 10.1145/332306.332326
DA - 2000-04-08
UR - https://www.deepdyve.com/lp/association-for-computing-machinery/human-and-mouse-gene-structure-comparative-analysis-and-application-to-7M7ZI240qU
DP - DeepDyve
ER -