TY - JOUR
AU - Nowak, Martin A.
AB - SCIENTIFIC CORRESPONDENCE synonymous substitutions and therefore Causes of HIV diversity predict a constant ratio of d J dn during infection. SrR - The human immunodeficiency flanking regions. We derived the mean Phylogenetic analysis of the viral virus (HIV) is characterized by enormous number of nucleotide substitutions sequences reveals a division into two per synonymous site, d,, and per non­ genetic flexibility, which gives rise to drug major lineages after year 3 (see ref. 4), resistance, escape from immune responses synonymous site, d n, for all pairwise which correspond to preferentially and failure of vaccination attempts. There comparisons of sequences in the samples macrophage-tropic or T-cell-line-adapted is much discussion about the factors con­ taken at years 3, 4, 5, 6 and 7 after phenotypes • Comparison of the tributing to viral diversity in individual infection. At year 0 the sequences were sequences in these two lineages (regard­ infections. It is clear that the high error completely homogeneous. less to the sampling time point) reveals that the d Jd ratio is significantly lower in rate of the reve rse transcriptase and the The figur e shows d,, dn, dJdn and the 0 CD4 cell count for years 3, 4, 5, 6 
TI - Causes of HIV diversity
JF - Nature
DO - 10.1038/376125a0
DA - 1995-07-13
UR - https://www.deepdyve.com/lp/springer-journals/causes-of-hiv-diversity-7vL6cNvKC8
SP - 125
EP - 125
VL - 376
IS - 6536
DP - DeepDyve
ER -