TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on November 18, 2021 - Published by Cold Spring Harbor Laboratory Press Histone H3 specific acetyltransferases are essential for cell cycle progression 1 2 3 1,5 4 1 LeAnn Howe, Darryl Auston, Patrick Grant, Sam John, Richard G. Cook, Jerry L. Workman, 2,6 and Lorraine Pillus Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA; Division of Biology, University of California, San Diego, California 92093, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA; Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA Longstanding observations suggest that acetylation and/or amino-terminal tail structure of histones H3 and H4 are critical for eukaryotic cells. For Saccharomyces cerevisiae, loss of a single H4-specific histone acetyltransferase (HAT), Esa1p, results in cell cycle defects and death. In contrast, although several yeast HAT complexes preferentially acetylate histone H3, the catalytic subunits of these complexes are not essential for viability. To resolve the apparent paradox between the significance of H3 versus H4 acetylation, we tested the hypothesis that H3 modification is essential, but is accomplished through combined activities of two enzymes. We observed that 
TI - Histone H3 specific acetyltransferases are essential for cell cycle progression
JF - Genes & Development
DO - 10.1101/gad.931401
DA - 2001-12-01
UR - https://www.deepdyve.com/lp/unpaywall/histone-h3-specific-acetyltransferases-are-essential-for-cell-cycle-89XNU0QKRI
DP - DeepDyve
ER -