TY - JOUR
AU - Ansermino, J. Mark
AB - Predicting Fluid Responsiveness in Children: A Systematic Review Heng Gan, MBBCh, MRCPCH, FRCA,*† Maxime Cannesson, MD, PhD,‡ John R. Chandler, MBBCh, FCARCSI, FDSRDS,§ and J. Mark Ansermino, MBBCh, MSc (Inf), FFA (SA), FRCPC*† BACKGROUND: Administration of fluid to improve cardiac output is the mainstay of hemody- namic resuscitation. Not all patients respond to fluid therapy, and excessive fluid administra- tion is harmful. Predicting fluid responsiveness can be challenging, particularly in children. Numerous hemodynamic variables have been proposed as predictors of fluid responsiveness. Dynamic variables based on the heart–lung interaction appear to be excellent predictors of fluid responsiveness in adults, but there is no consensus on their usefulness in children. METHODS: We systematically reviewed the current evidence for predictors of fluid respon- siveness in children. A systematic search was performed using PubMed (1947–2013) and EMBASE (1974–2013). Search terms included fluid, volume, response, respond, challenge, bolus, load, predict, and guide. Results were limited to studies involving pediatric subjects (infant, child, and adolescent). Extraction of data was performed independently by 2 authors using predefined data fields, including study quality indicators. Any variable with an area under the receiver operating characteristic curve that was significantly above 0.5 was considered predictive. RESULTS: Twelve studies involving 
TI - Predicting Fluid Responsiveness in Children  A Systematic Review
JF - Anesthesia & Analgesia
DO - 10.1213/ANE.0b013e3182a9557e
DA - 2013-12-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/predicting-fluid-responsiveness-in-children-a-systematic-review-8CEUs0UO1S
SP - 1380–1392-1380&ndash
EP - ndash;1392-1380–1392
VL - 117
IS - 6
DP - DeepDyve
ER -