TY - JOUR
AU - Turner, Martin
AB - Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and are defective in their primary and secondary responses to thymus-dependent antigen. p110δ−/− B cells proliferate poorly in response to B cell receptor (BCR) or CD40 signals in vitro, fail to activate protein kinase B, and are prone to apoptosis. p110δ function is required for BCR-mediated calcium flux, activation of phosphlipaseCγ2, and Bruton's tyrosine kinase. Thus, p110δ plays a critical role in B cell homeostasis and function.
TI - A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
JF - The Journal of Experimental Medicine
DO - 10.1084/jem.20020805
DA - 2002-09-16
UR - https://www.deepdyve.com/lp/pubmed-central/a-crucial-role-for-the-p110-subunit-of-phosphatidylinositol-3-kinase-8R0YF1wEkK
SP - 753
EP - 763
VL - 196
IS - 6
DP - DeepDyve
ER -