TY - JOUR
AU1 - Christiansen, Jan
AU2 - Kolte, Astrid M
AU3 - Hansen, Thomas v O
AU4 - Nielsen, Finn C
AB - Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D.
TI - IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes
JF - Journal of Molecular Endocrinology
DO - 10.1677/jme-09-0016
DA - 2009-05-08
UR - https://www.deepdyve.com/lp/bioscientifica/igf2-mrna-binding-protein-2-biological-function-and-putative-role-in-8WoEy3yukP
SP - 187
EP - 195
VL - 43
IS - 5
DP - DeepDyve
ER -