TY - JOUR
AU - Sigler, Paul B.
AB - Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5′-AGGTCA-3′ separated by one to five base pairs. The 1.9 Å crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.
TI - Structural determinants of nuclear receptor assembly on DNA direct repeats
JF - Nature
DO - 10.1038/375203a0
DA - 1995-05-18
UR - https://www.deepdyve.com/lp/springer-journals/structural-determinants-of-nuclear-receptor-assembly-on-dna-direct-9IENGLDXJJ
SP - 203
EP - 211
VL - 375
IS - 6528
DP - DeepDyve
ER -