TY - JOUR
AU - Spurr, Nigel K.
AB - Human Molecular Genetics, 2005, Vol. 14, No. 17 2485–2488 doi:10.1093/hmg/ddi252 Advance Access published on July 21, 2005 COMMENTARY Guidelines for conducting and reporting whole genome/large-scale association studies 1 1 2, Margaret G. Ehm , Matthew R. Nelson and Nigel K. Spurr 1 2 Design and Standards, GlaxoSmithKline, Research Triangle Park, NC, USA and Portfolio Genetics, GlaxoSmithKline, Stevenage, Herts, UK Received June 30, 2005; Accepted July 11, 2005 Many studies have tested for association with a trait, using a individual genotyping using a range of platforms (13–15). few to hundreds, and in some cases thousands, of genetic var- Patient samples may include multiple samples of nuclear iants. However, very few of the reported genetic associations families, cases and controls or other association designs. for complex traits have been confirmed when tested in inde- Several WGA studies have been performed on samples pendent sample collections (1). Several factors have made collected in small, isolated populations genotyped for identification of replicable genetic associations, especially thousands of STR markers (16–20). With the rapid growth for complex diseases, a challenge. Nevertheless, there are of inexpensive, high-throughput genotyping, studies within several examples of successful attempts to identify genes large, non-isolate populations are beginning to emerge 
TI - Guidelines for conducting and reporting whole genome/large-scale association studies
JF - Human Molecular Genetics
DO - 10.1093/hmg/ddi252
DA - 2005-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/guidelines-for-conducting-and-reporting-whole-genome-large-scale-9Q0Ejr57pS
SP - 2485
EP - 2488
VL - 14
IS - 17
DP - DeepDyve
ER -