TY - JOUR
AU - Kingston, Robert E.
AB - 


 PcG and trxG genes comprise a maintenance system for gene expression. 


 PcG repression is targeted to silent genes, suggesting that these proteins differentiate between active and inactive states; PcG and trxG might differentially recognize chromatin features of active versus inactive genes. 


 PcG repression might occur through effects on chromatin structure. 


 Models for how PcG proteins repress gene expression suggest that PcG proteins are a structural component of repressed chromatin, or alternatively, have chromatin-organizing properties. 


 PcG proteins form large complexes, the biochemical activities of which are largely unknown but might include histone modification. 


 The trxG maintains active gene expression, probably also at the level of chromatin structure. 


 Some trxG genes encode components of chromatin-remodelling complexes. 


 Targeting of PcG and trxG complexes might occur through sequence-specific DNA-binding proteins that are implicated in both PcG and trxG function. 


 It is not known how PcG and trxG proteins maintain expression states through cell division, but stable marks on chromatin probably have a role.



TI - Mechanisms of transcriptional memory
JF - Nature Reviews Molecular Cell Biology
DO - 10.1038/35073039
DA - 2001-06-01
UR - https://www.deepdyve.com/lp/springer-journals/mechanisms-of-transcriptional-memory-9RRezjaY6g
SP - 409
EP - 421
VL - 2
IS - 6
DP - DeepDyve
ER -