TY - JOUR
AU - Baldwin, A S
AB - Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB) signaling pathway in controlling the initiation and progression of human cancer. NF-κB and associated regulatory proteins such as IκB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-κB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-κB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-κB. Additionally, the effects of NF-κB activation in tumors relative to cancer therapy are also discussed.
TI - Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
JF - Oncogene
DO - 10.1038/sj.onc.1209942
DA - 2006-10-30
UR - https://www.deepdyve.com/lp/springer-journals/nuclear-factor-b-and-inhibitor-of-b-kinase-pathways-in-oncogenic-9W3PG70A0w
SP - 6817
EP - 6830
VL - 25
IS - 51
DP - DeepDyve
ER -