TY - JOUR
AU1 - Audebert, Marc
AU2 - Salles, Bernard
AU3 - Calsou, Patrick
AU4 - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 53, Issue of December 31, pp. 55117–55126, 2004 © 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining* Received for publication, April 23, 2004, and in revised form, October 19, 2004 Published, JBC Papers in Press, October 21, 2004, DOI 10.1074/jbc.M404524200 Marc Audebert‡, Bernard Salles§, and Patrick Calsou From the Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, F-31077 Toulouse Cedex, France recombination but also toxic lesions produced by collapsed The efficient repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integ- DNA replication forks and by DNA-damaging agents such as rity. In mammalian cells, the nonhomologous end-join- ionizing radiation (IR) or reactive oxygen species. Repair of ing process that represents the predominant repair DSBs is critical for the maintenance of genomic integrity be- pathway relies on the DNA-dependent protein kinase cause unproperly repaired breaks can lead to cancer via chro- (DNA-PK) and the XRCC4-DNA ligase IV complex. None- mosomal aberrations (1, 2). theless, several in vitro and in 
TI - Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m404524200
DA - 2004-12-01
UR - https://www.deepdyve.com/lp/unpaywall/involvement-of-poly-adp-ribose-polymerase-1-and-xrcc1-dna-ligase-iii-9XZLA0pHoR
DP - DeepDyve
ER -