TY - JOUR
AU - Brewer, Gary
AB - (A+U)-rich elements (AREs) within 3′ untranslated regions are signals for rapid degradation of messenger RNAs encoding many oncoproteins and cytokines. The ARE-binding protein AUF1 contributes to their degradation. We identified MYC proto-oncogene mRNA as a cellular AUF1 target. Levels of MYC translation and cell proliferation were proportional to AUF1 abundance but inversely proportional to the abundance of the ARE-binding protein TIAR, a MYC translational suppressor. Both AUF1 and TIAR affected MYC translation via the ARE without affecting mRNA abundance. Altering association of one ARE-binding protein with MYC mRNA in vivo reciprocally affected mRNA association with the other protein. Finally, genetic experiments revealed that AUF1 and TIAR control proliferation by a MYC-dependent pathway. Together, these observations suggest a novel regulatory mechanism where tuning the ratios of AUF1 and TIAR bound to MYC mRNA permits dynamic control of MYC translation and cell proliferation.
TI - Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation
JF - Nature Structural & Molecular Biology
DO - 10.1038/nsmb1249
DA - 2007-05-07
UR - https://www.deepdyve.com/lp/springer-journals/competitive-binding-of-auf1-and-tiar-to-myc-mrna-controls-its-9ZzBULn0FU
SP - 511
EP - 518
VL - 14
IS - 6
DP - DeepDyve
ER -