TY - JOUR AU - AB - This paper is available online at www.jbc.org ACCELERATED PUBLICATION THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 284, NO. 28, pp. 18588 –18592, July 10, 2009 © 2009 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A. phosphorylation (5), our repeated efforts to prove p53 as a Plk1-mediated Phosphorylation direct target of Plk1 have been unsuccessful. □ S Topors was discovered in a screen searching for proteins that of Topors Regulates p53 Stability bind to DNA topoisomerase I (6) and was also identified as a Received for publication, March 31, 2009, and in revised form, May 20, 2009 Published, JBC Papers in Press, May 27, 2009, DOI 10.1074/jbc.C109.001560 p53-binding protein (7). Although Topors is widely expressed ‡§1 § § ¶ Xiaoming Yang , Hongchang Li , Zinan Zhou , Wen-Horng Wang , in normal human tissues, its expression is decreased or unde- ‡ ¶ §2 Anping Deng , Ourania Andrisani , and Xiaoqi Liu tectable in colon, lung, and brain adenocarcinomas, indicating From the College of Chemistry, Sichuan University, Chengdu 610064, China that it might function as a tumor suppressor (8). Topors con- § ¶ and the Departments of Biochemistry and Basic Medical Sciences, Purdue tains TI - Plk1-mediated Phosphorylation of Topors Regulates p53 Stability JF - Journal of Biological Chemistry DO - 10.1074/jbc.c109.001560 DA - 2009-07-01 UR - https://www.deepdyve.com/lp/unpaywall/plk1-mediated-phosphorylation-of-topors-regulates-p53-stability-9b2NAIuqrA DP - DeepDyve ER -