TY - JOUR
AU - Tilley, Douglas G.
AB - This Review is the first in a thematic series on Novel Aspects of Cardiovascular G Protein-Coupled Receptor Signaling: Implications for New Therapeutics, which includes the following articles: Introduction to the Series Biased Ligands for Better Cardiovascular Drugs: Dissecting GPCR Pharmacology G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function Compartmentalization of 
-Adrenergic Signals in Cardiomyocytes G Protein-Coupled Receptor Kinases (GRKs) as Therapeutic Targets in Cardiovascular Disease Regulators of G Protein Signaling in the Heart and Their Potential as Therapeutic Targets Howard Rockman, Guest Editor G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function Douglas G. Tilley Abstract: G protein-coupled receptors signal through a variety of mechanisms that impact cardiac function, including contractility and hypertrophy. G protein–dependent and G protein–independent pathways each have the capacity to initiate numerous intracellular signaling cascades to mediate these effects. G protein–dependent signaling has been studied for decades and great strides continue to be made in defining the intricate pathways and effectors regulated by G proteins and their impact on cardiac function. G protein–independent signaling is a relatively newer concept that is being explored more frequently in the cardiovascular system. Recent studies have begun to reveal how 
TI - G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function
JF - Circulation Research
DO - 10.1161/CIRCRESAHA.110.231225
DA - 2011-07-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/g-protein-ndash-dependent-and-g-protein-ndash-independent-signaling-9fWtxHIufJ
SP - 217–230-217&ndash
EP - ndash;230-217–230
VL - 109
IS - 2
DP - DeepDyve
ER -