TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on December 10, 2021 - Published by Cold Spring Harbor Laboratory Press Yin Yang 1 is a critical regulator of B-cell development 1 1,2 1,7 3 1,4 Huifei Liu, Marc Schmidt-Supprian, Yujiang Shi, Elias Hobeika, Natasha Barteneva, 3 3,8 3 5,6 1,2 1,9 Hassan Jumaa, Roberta Pelanda, Michael Reth, Jane Skok, Klaus Rajewsky, and Yang Shi 1 2 Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA; CBR Institute for Biomedical Research, Inc., Boston, Massachusetts 02115, USA; Institute for Biology III, Albert-Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany; Flow cytometry core facility, CBR Institute for Biomedical Research, Inc., Boston, Massachusetts 02115, USA; Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued by a prerearranged IgH transgene. Three-dimensional DNA fluorescence in situ hybridization analysis revealed an important function for YY1 
TI - Yin Yang 1 is a critical regulator of B-cell development
JF - Genes & Development
DO - 10.1101/gad.1529307
DA - 2007-05-15
UR - https://www.deepdyve.com/lp/unpaywall/yin-yang-1-is-a-critical-regulator-of-b-cell-development-9i07tZfDzQ
DP - DeepDyve
ER -