TY - JOUR
AU - Schurr, Erwin
AB - SignificanceType-1 reactions (T1R) are pathological immune responses in leprosy and a frequent cause of peripheral nerve damage. Employing a candidate gene approach combined with deep resequencing, we identified amino acid mutations in the E3 ligase Parkin and the polyfunctional kinase LRRK2 that were associated with T1R. This finding directly linked both proteins with the extent of the immune response in an infectious disease. Moreover, amino acids associated with T1R mutations were significantly enriched for mutations found in patients suffering from Parkinson’s disease (PD). These findings confirm Parkin and LRRK2 as 2 key inflammatory regulators and suggest that T1R and PD share overlapping pathways of pathogenesis.
TI - Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease
JF - Proceedings of the National Academy of Sciences of the United States of America
DO - 10.1073/pnas.1901805116
DA - 2019-07-15
UR - https://www.deepdyve.com/lp/pubmed-central/pleiotropic-effects-for-parkin-and-lrrk2-in-leprosy-type-1-reactions-9wTUtPTrfp
SP - 15616
EP - 15624
VL - 116
IS - 31
DP - DeepDyve
ER -