TY - JOUR
AU1 - Arthur, Rhonda
AU2 - Møller, Henrik
AU3 - Garmo, Hans
AU4 - Häggström, Christel
AU5 - Holmberg, Lars
AU6 - Stattin, Pär
AU7 - Malmström, Håkan
AU8 - Lambe, Mats
AU9 - Hammar, Niklas
AU1 - Walldius, Göran
AU1 - Robinson, David
AU1 - Jungner, Ingmar
AU1 - Hemelrijck, Mieke
AB - Purpose Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglyc- erides, and total cholesterol with prostate cancer death. Methods From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox pro- portional hazards regression models were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers. Results Using clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02–1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death. Conclusion Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression. 
TI - Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study
JF - Cancer Causes & Control
DO - 10.1007/s10552-018-1093-1
DA - 2018-11-12
UR - https://www.deepdyve.com/lp/springer-journals/serum-glucose-triglycerides-and-cholesterol-in-relation-to-prostate-A3kCf0Qs0I
SP - 195
EP - 206
VL - 30
IS - 2
DP - DeepDyve
ER -