TY - JOUR
AU - ,
AB - We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
TI - SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
JF - Nature Medicine
DO - 10.1038/s41591-020-0868-6
DA - 2020-05-23
UR - https://www.deepdyve.com/lp/springer-journals/sars-cov-2-entry-factors-are-highly-expressed-in-nasal-epithelial-A4IhGp60fD
SP - 681
EP - 687
VL - 26
IS - 5
DP - DeepDyve
ER -