TY - JOUR AU - Korein , , J. AB - The diagnosis and management of patients with persistent vegetative (PVS) and minimally conscious (MCS) states entail powerful medical, ethical and legal debates. The recent description of the MCS highlights the crucial role of unexpected and well-documented recoveries of cognitive functions. Functional neuroimaging has provided new insights for assessing neuropathology and cerebral activity in these patients, providing information on the presence, degree, and location of any residual brain function in patients with PVS or MCS. We present a review on this topic, emphasizing the clinical and neuroimaging assessment of these states, with some of our recent results in this area. We conclude that the development of rehabilitation techniques for patients with PVS and others suffering long-lasting effects of brain injury is a crucial challenge for actual and future generations of neuroscientists. KEY WORDS persistent vegetative state, minimally conscious state, consciousness, awareness, SPECT, fractional anisotropy, magnetic resonance imaging INTRODUCTION Terry Schiavo and other famous patients, including Karen Ann Quinlan and Nancy Cruzan in Address for Correspondence: Dr. Calixto Machado, M.D., Ph.D. Institute of Neurology and Neurosurgery Apartado Postal 4268 Ciudad de La Habana 10400, Cuba e-mail: braind@infomed.sld.cu the USA, and Tony Bland in the UK, raised new controversies about the TI - Persistent Vegetative and Minimally Conscious States JF - Reviews in the Neurosciences DO - 10.1515/REVNEURO.2009.20.3-4.203 DA - 2009-08-01 UR - https://www.deepdyve.com/lp/de-gruyter/persistent-vegetative-and-minimally-conscious-states-A8S6Lmfqsf SP - 203 VL - 20 IS - DP - DeepDyve ER -