TY - JOUR
AU1 - Stein, Rhona
AU2 - Blumenthal, Rosalyn
AU3 - Sharkey, Robert M.
AU4 - Goldenberg, David M.
AB - Background. RS7 is a murine monoclonal antibody immunoglobulin G1 with pancarcinoma reactivity, which was raised against human squamous cell carcinoma of the lung. To optimize the use of monoclonal antibody RS7 as a carrier of radionuclides for tumor targeting and therapeutic applications, whole RS7 immunoglobulin G and its F(ab′)2 fragment were radiolabeled, and their biodistribution and effectiveness as radioimmunotherapeutic agents in nude mice bearing established human tumor xenografts were evaluated. The contributions of the tumor model, monoclonal antibody form (fragment vs. intact), radioisotope (131I, 111In, 90Y, and 188Re), and antigen target were evaluated.
TI - Comparative biodistribution and radioimmunotherapy of monoclonal antibody rs7 and its f(ab′)2 in nude mice bearing human tumor xenografts
JF - Cancer
DO - 10.1002/1097-0142(19940201)73:3+<816::AID-CNCR2820731311>3.0.CO;2-T
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/wiley/comparative-biodistribution-and-radioimmunotherapy-of-monoclonal-AAK552Hq9d
SP - 816
EP - 823
VL - 73
IS - S3
DP - DeepDyve
ER -