TY - JOUR
AU - Hurley, Laurence H.
AB - c-MYC is an important regulator of a wide array of cellular processes necessary for normal cell growth and differentiation, and its dysregulation is one of the hallmarks of many cancers. Consequently, understanding c- MYC transcriptional activation is critical for understanding developmental and cancer biology, as well as for the development of new anticancer drugs. The nuclease hypersensitive element (NHE) III 1 region of the c- MYC promoter has been shown to be particularly important in regulating c- MYC expression. Specifically, the formation of a G-quadruplex structure appears to promote repression of c- MYC transcription. This review focuses on what is known about the formation of a G-quadruplex in the NHE III 1 region of the c- MYC promoter, as well as on those factors that are known to modulate its formation. Last, we discuss the development of small molecules that stabilize or induce the formation of G-quadruplex structures and could potentially be used as anticancer agents.
TI - The c- MYC NHE III 1 : Function and Regulation
JF - Annual Review of Pharmacology and Toxicology
DO - 10.1146/annurev.pharmtox.48.113006.094649
DA - 2010-02-10
UR - https://www.deepdyve.com/lp/annual-reviews/the-c-myc-nhe-iii-1-function-and-regulation-AZ8NHq0QAd
SP - 111
EP - 129
VL - 50
IS - 
DP - DeepDyve
ER -