TY - JOUR
AU - DU, Yasong
AB - BackgroundAdolescent depression results in severe and protracted suffering for affected individuals and 
their family members, but the underlying mechanism of this disabling condition remains unclear.ObjectivesCompare resting-state brain functioning between first-episode, drug-naïve adolescents with 
major depressive disorder and matched controls.MethodsFifteen adolescents with major depressive disorder and 16 controls underwent a resting-state 
fMRI scan performed using a 3T magnetic resonance scanner. The amplitude of low frequency fluctuation 
(ALFF) was used to assess resting-state brain function. ResultsAdolescents with depression had higher mean (sd) scores on the Children Depression Inventory 
(CDI) than controls (22.13 [9.21] vs. 9.37 [5.65]). Compared with controls, adolescents with depression had 
higher ALFF in the posterior cingulate gyrus, left inferior temporal gyrus, right superior temporal gyrus, right 
insula, right parietal lobe, and right fusiform gyrus; they also exhibited lower ALFF in the bilateral cuneus, 
the left occipital lobe, and the left medial frontal lobe.ConclusionsAdolescent depression is associated with significant changes in the functioning of several 
regions of the brain.
TI - Case-control resting-state fMRI study of brain functioning among adolescents with first-episode major depressive disorder
JF - Shanghai Archives of Psychiatry
DO - 10.3969/j.issn.1002-0829.2014.04.004
DA - 2014-08-01
UR - https://www.deepdyve.com/lp/pubmed-central/case-control-resting-state-fmri-study-of-brain-functioning-among-B4aGh10lok
SP - 207
EP - 215
VL - 26
IS - 4
DP - DeepDyve
ER -