TY - JOUR
AU - Foord, Steven M.
AB - Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.
TI - RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
JF - Nature
DO - 10.1038/30666
DA - 1998-05-28
UR - https://www.deepdyve.com/lp/springer-journals/ramps-regulate-the-transport-and-ligand-specificity-of-the-calcitonin-B7M03VSHZ0
SP - 333
EP - 339
VL - 393
IS - 6683
DP - DeepDyve
ER -