TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 34, Issue of August 22, pp. 32471–32477, 2003 © 2003 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. STAT4 Requires the N-terminal Domain for Efficient Phosphorylation* Received for publication, March 18, 2003, and in revised form, June 6, 2003 Published, JBC Papers in Press, June 12, 2003, DOI 10.1074/jbc.M302776200 Hua-Chen Chang‡§ , Shangming Zhang‡§, India Oldham‡§, Lisa Naeger , Timothy Hoey , and Mark H. Kaplan‡§** From the ‡Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, the §Walther Cancer Institute, Indianapolis, Indiana 46208, and Tularik, Incorporated, San Francisco, California 94080 pathogenic stimulation. Thus, IL-12 is an important regulator STAT4 (signal transducer and activator of transcrip- tion-4) mediates biological effects in response to inter- in innate and adaptive immunity. leukin-12 (IL-12). STAT4 has multiple domains that have IL-12 mediates its biological function by binding to IL-12 distinct functions in signaling and gene activation. To receptors (IL-12Rs) and transmitting signals via the JAK- characterize the role of the STAT4 N-terminal domain in STAT pathway. IL-121 and IL-12R2 belong to the gp130 mediating STAT4 biological function, we have gener- 
TI - STAT4 Requires the N-terminal Domain for Efficient Phosphorylation
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m302776200
DA - 2003-08-01
UR - https://www.deepdyve.com/lp/unpaywall/stat4-requires-the-n-terminal-domain-for-efficient-phosphorylation-B8Qv010Gsq
DP - DeepDyve
ER -