TY - JOUR
AU - Chan, David C
AB - Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria). A heptad repeat region (HR2) mediates mitofusin oligomerization by assembling a dimeric, antiparallel coiled coil. The transmembrane segments are located at opposite ends of the 95 angstrom coiled coil and provide a mechanism for organelle tethering. Consistent with this proposal, truncated mitofusin, in an HR2-dependent manner, causes mitochondria to become apposed with a uniform gap. Our results suggest that HR2 functions as a mitochondrial tether before fusion.
TI - Structural basis of mitochondrial tethering by mitofusin complexes.
JF - Science
DO - 10.1126/science.1099793
DA - 2004-08-27
UR - https://www.deepdyve.com/lp/pubmed/structural-basis-of-mitochondrial-tethering-by-mitofusin-complexes-BBLR90nn3Q
SP - 858
EP - 6285862
VL - 305
IS - 5685
DP - DeepDyve
ER -