TY - JOUR
AU - Flintoft, Louisa
AB - RE SEARCH HIGHLIGHT S URLs G E N ETI C D I S EA S E A recent study has revealed a new DNA polymerase in vitro in differ- potential mechanism of mitochon- ent dNTP conditions. The enzyme drial mutagenesis, indicating that an proved to be highly accurate when unequal distribution of nucleotides all nucleotides were present in equal might hold the key to some human concentrations. However, skewing diseases. the pool to represent the situation in The mitochondrial genome is re- mitochondria resulted in a several- nowned for playing by its own rules. It fold increase in the rate of replication has a different structure and mode of errors. The types of mistake made by inheritance to that of nuclear DNA, the polymerase were also influenced and also shows a much faster rate of by the excess dGTP in the mito- mutation, with changes occurring up chondrial pool — A•T to G•C tran- to 100-fold more frequently than in sitions predominated, reflecting an the nuclear genome. This last pecu- increased tendency for the dGTP to liarity is particularly interesting, as be used incorrectly by the polymer- mitochondrial mutations contribute ase when its levels are high. to a range 
TI - Mitochondria: uncovering the error of their ways
JF - Nature Reviews Genetics
DO - 10.1038/nrg1625
DA - 2005-05-01
UR - https://www.deepdyve.com/lp/springer-journals/mitochondria-uncovering-the-error-of-their-ways-BG8EOCuxk1
SP - 345
EP - 345
VL - 6
IS - 5
DP - DeepDyve
ER -