TY - JOUR AU - AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 48, Issue of November 28, pp. 47877–47889, 2003 © 2003 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Dissection of the Functional Differences between Sarco(endo)plasmic Reticulum Ca -ATPase (SERCA) 1 and 2 Isoforms and Characterization of Darier Disease (SERCA2) □ S Mutants by Steady-state and Transient Kinetic Analyses* Received for publication, June 25, 2003, and in revised form, September 4, 2003 Published, JBC Papers in Press, September 15, 2003, DOI 10.1074/jbc.M306784200 ¶ ¶ Leonard Dode‡§, Jens Peter Andersen , Natalie Leslie‡, Jittima Dhitavat‡, Bente Vilsen , and Alain Hovnanian**‡‡ From ‡The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom, the Department of Physiology, University of Aarhus, Ole Worms Alle ´ 160, DK-8000 Aarhus C, Denmark, and **INSERM U563, Pavillon Lefebvre, Purpan Hospital, Place de Dr Baylac, 31059 Toulouse Cedex 3, France Steady-state and rapid kinetic studies were con- In this case, the disease may be a consequence of the low ducted to functionally characterize the overall and par- expression level and/or reduction of Ca affinity and 2 2 tial reactions of the Ca transport cycle mediated by sensitivity TI - Dissection of the Functional Differences between Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) 1 and 2 Isoforms and Characterization of Darier Disease (SERCA2) Mutants by Steady-state and Transient Kinetic Analyses JF - Journal of Biological Chemistry DO - 10.1074/jbc.m306784200 DA - 2003-11-01 UR - https://www.deepdyve.com/lp/unpaywall/dissection-of-the-functional-differences-between-sarco-endo-plasmic-BHmifk8R6z DP - DeepDyve ER -