TY - JOUR
AU - Di Croce, Luciano
AB - Methylation of H3K27 by Polycomb repressive complex 2 (PRC2) is essential for gene regulation. A new study provides structural evidence for the recognition of di- and trimethylated H3K36 by the Tudor domain of PRC2 subunit Phf19 as well as functional data suggesting that recognition of di- or trimethylated Phf19–H3K36 is required for regulating PRC2 activity and for full repression of selected PRC2 targets in embryonic stem cells.
TI - Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
JF - Nature Structural & Molecular Biology
DO - 10.1038/nsmb.2434
DA - 2012-10-28
UR - https://www.deepdyve.com/lp/springer-journals/phf19-links-methylated-lys36-of-histone-h3-to-regulation-of-polycomb-BK2T0k0GoD
SP - 1257
EP - 1265
VL - 19
IS - 12
DP - DeepDyve
ER -