TY - JOUR
AU - Baltimore, D
AB - A Src homology 3 (SH3) region is a sequence of approximately 50 amino acids found in many nonreceptor tyrosine kinases and other proteins. Deletion of the SH3 region from the protein encoded by the c-abl proto-oncogene activates the protein's transforming capacity, thereby suggesting the participation of the SH3 region in the negative regulation of transformation. A complementary DNA was isolated that encoded a protein, 3BP-1, to which the SH3 region of Abl bound with high specificity and to which SH3 regions from other proteins bound differentially. The sequence of the 3BP-1 protein is similar to that of a COOH-terminal segment of Bcr and to guanosine triphosphatase-activating protein (GAP)-rho, which suggests that it might have GAP activity for Ras-related proteins. The 3BP-1 protein may therefore be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.
TI - Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho.
JF - Science (New York, N.Y.)
DO - 10.1126/science.1379745
DA - 1992-09-08
UR - https://www.deepdyve.com/lp/pubmed/identification-of-a-protein-that-binds-to-the-sh3-region-of-abl-and-is-Bh2wS9zNy1
SP - 803
EP - 6
VL - 257
IS - 5071
DP - DeepDyve
ER -