TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 47, Issue of November 23, pp. 44247–44257, 2001 © 2001 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. AKAP-Lbc Anchors Protein Kinase A and Nucleates G -selective Rho-mediated Stress Fiber Formation* Received for publication, July 16, 2001, and in revised form, September 5, 2001 Published, JBC Papers in Press, September 6, 2001, DOI 10.1074/jbc.M106629200 Dario Diviani, Jacquelyn Soderling, and John D. Scott‡ From the Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 Guanine nucleotide exchange factors of the Dbl family exchange factors such as PDZ Rho-GEF, KIAA0380, or relay signals from membrane receptors to Rho family GTRAP48 (12–14). GTPases. We now demonstrate that a longer transcript A universal hallmark of exchange factors that activate GTP- of the Lbc gene encodes a chimeric molecule, which we ases of the Rho family is a conserved region of 
250 residues have called AKAP-Lbc, that functions as an A-kinase- that contains a Dbl homology (DH) domain followed by a pleck- anchoring protein (AKAP) and a Rho-selective guanine strin homology domain (9). The DH domain contains the nu- nucleotide exchange factor. Expression of AKAP-Lbc in cleotide 
TI - AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m106629200
DA - 2001-11-01
UR - https://www.deepdyve.com/lp/unpaywall/akap-lbc-anchors-protein-kinase-a-and-nucleates-g-12-selective-rho-ByiJhfZZlr
DP - DeepDyve
ER -