TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 34, Issue of August 24, pp. 32282–32287, 2001 © 2001 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin* Received for publication, May 22, 2001 Published, JBC Papers in Press, June 26, 2001, DOI 10.1074/jbc.M104661200 Kurtis E. Bachman‡§, Michael R. Rountree‡, and Stephen B. Baylin‡¶ From the ‡The Johns Hopkins Oncology Center, Tumor Biology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 and §The Graduate Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 We demonstrate that the recently identified DNA quired for the establishment and maintenance of genomic methylation patterns and proper murine development (3, 4). methyltransferases, Dnmt3a and Dnmt3b, like DNMT1, repress transcription in a methylation-independent Mutations in DNMT3B have been found to cause the develop- manner. Dnmt3a and Dnmt3b repress transcription pri- mental syndrome, ICF, which is characterized by a loss of marily through a plant homeodomain-like motif that is methylation at pericentromeric heterochromatin (4 – 6). shared with the ATRX protein but is not present in Dnmt3a and Dnmt3b are 
TI - Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m104661200
DA - 2001-08-01
UR - https://www.deepdyve.com/lp/unpaywall/dnmt3a-and-dnmt3b-are-transcriptional-repressors-that-exhibit-unique-C5B5ghCmrJ
DP - DeepDyve
ER -