TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on December 4, 2021 - Published by Cold Spring Harbor Laboratory Press The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos Anne E. Chambers, Malcolm Logan, Surendra Kotecha, Norma Towers, Duncan Sparrow, and Timothy J. Mohun 1 Laboratory of Developmental Biochemistry, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK We have examined the role of two RSRF/MEF2 proteins in the onset of skeletal and cardiac muscle differentiation in early Xenopus embryos. In normal development, zygotic expression of SL1 (MEF2D) precedes that of SL2 (MEF2A) by several hours, but neither gene is expressed prior to the accumulation of MyoD and Myf5 transcripts in the somitic mesoderm. Ectopic expression of the myogenic factors in explants of presumptive ectoderm induces expression of both SLI and SL2, whereas in reciprocal experiments, neither RSRF protein activates the endogenous myoD or Myf5 genes. We conclude that SL1 and SL2 lie downstream of these myogenic factors in the skeletal myogenic pathway. SL1 is distinguished from SL2 in being expressed in the presumptive heart region of the early tailbud embryo, prior to detection of any markers for cardiac muscle differentiation. Furthermore, ectopic 
TI - The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos.
JF - Genes & Development
DO - 10.1101/gad.8.11.1324
DA - 1994-06-01
UR - https://www.deepdyve.com/lp/unpaywall/the-rsrf-mef2-protein-sl1-regulates-cardiac-muscle-specific-CDmQ6Vry0C
DP - DeepDyve
ER -