TY - JOUR
AU - Davies, Peter
AB - 5446 • The Journal of Neuroscience, June 1, 2005 • 25(22):5446 –5454 Neurobiology of Disease Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms 1 2 2 3 4 1,2 Cathy Andorfer, Christopher M. Acker, Yvonne Kress, Patrick R. Hof, Karen Duff, and Peter Davies 1 2 3 Departments of Neuroscience and Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, and Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, and Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962 Mutations in the microtubule-associated protein tau gene have been linked to neurofibrillary tangle (NFT) formation in several neuro- degenerative diseases known as tauopathies; however, no tau mutations occur in Alzheimer’s disease, although this disease is also characterized by NFT formation and cell death. Importantly, the mechanism of tau-mediated neuronal death remains elusive. Aged mice expressing nonmutant human tau in the absence of mouse tau (htau mice) developed NFTs and extensive cell death. The mechanism of neuron death was investigated in htau mice, and surprisingly, the presence of tau filaments did 
TI - Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms
JF - Journal of Neuroscience
DO - 10.1523/jneurosci.4637-04.2005
DA - 2005-06-01
UR - https://www.deepdyve.com/lp/unpaywall/cell-cycle-reentry-and-cell-death-in-transgenic-mice-expressing-CEXXrSwIMR
DP - DeepDyve
ER -