TY - JOUR
AU - Villoutreix, Bruno O.
AB - Brief Reviews Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway Novel Insights Into Structure–Function Relationships and Molecular Recognition Bjo¨rn Dahlba¨ck, Bruno O. Villoutreix Abstract—The protein C system provides important control of blood coagulation by regulating the activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively. The system comprises membrane-bound and circulating proteins that assemble into multi-molecular complexes on cell surfaces. Vitamin K–dependent protein C, the key component of the system, circulates in blood as zymogen to an anticoagulant serine protease. It is efficiently activated on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor (EPCR) further stimulates the protein C activation. Activated protein C (APC) together with its cofactor protein S inhibits coagulation by degrading FVIIIa and FVa on the surface of negatively charged phospholipid membranes. Efficient FVIIIa degradation by APC requires not only protein S but also intact FV, which like thrombin is a Janus-faced protein with both procoagulant and anticoagulant potential. In addition to its anticoagulant properties, APC has antiinflammatory and antiapoptotic functions, which are exerted when APC binds to EPCR and proteolytic cleaves protease-activated receptor 
TI - Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway Novel Insights Into Structure–Function Relationships and Molecular Recognition
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
DO - 10.1161/01.ATV.0000168421.13467.82
DA - 2005-07-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/regulation-of-blood-coagulation-by-the-protein-c-anticoagulant-pathway-CO5gxzgiPn
SP - 1311
EP - 1320
VL - 25
IS - 7
DP - DeepDyve
ER -