TY - JOUR
AU - Palyulin, V A
AB - Our investigation was motivated by a recent paper concerning "high-quality structure-property-activity regressions" (J. Chem. Inf. Comput. Sci. 2000, 40, 899-905) for boiling points of small sulfides using variable connectivity indices. We performed QSAR study of the same data set using a logically preselected solvation index and obtained a very good one-parameter regression. The structures of the whole possible set of small sulfides (C2-C6) were generated and the statistics were proven by real prediction using an external test set of sulfides. The variants of extended prediction with extrapolated data and QSAR using an expanded training set were also performed, and all these data also revealed the preference of the solvation index. A general problem of descriptive vs predictive QSAR is discussed.
TI - QSAR for boiling points of "small" sulfides. Are the "high-quality structure-property-activity regressions" the real high quality QSAR models?
JF - Journal of Chemical Information and Computer Sciences
DO - 10.1021/ci0001637
DA - 2001-09-13
UR - https://www.deepdyve.com/lp/pubmed/qsar-for-boiling-points-of-small-sulfides-are-the-high-quality-CQc0pJr1iy
SP - 1022
EP - 7
VL - 41
IS - 4
DP - DeepDyve
ER -