TY - JOUR
AU - Dancer, B N
AB - 103P DEVELOPMENT OF BlOClDE RESISTANCE IN BAC/LLUS SUBTlLlS 168 AND 17s SPORULATION (SPO') MUTANTS * * ** * ** A.G.Knott, A.D.Russel1, B.N.Dancer, Welsh School of Pharmacy and School of Pure and Applied Biology, University of Wales College of Cardiff, Cardiff CF1 3XF, Wales Comparatively little information is available about the development of biocide resistance during sporulation. It is, however, known that the dialdehyde, glutaraldehyde, is highly effective at low concentrations until a very late stage of sporulation (Power et al. 1988) whereas resistance to the bisbiguanide, chlorhexidine, is found at a much earlier stage (Shaker et al. 1988). In this report, we describe the stages involved in the development of resistance of Bacillus subtilis 168 and specific sporulation (Spo-) mutants to phenolics, an organomercurial, a monoaldehyde, chlorine-releasing agents, an anionic surfactant and a quaternary ammonium compound. Synchronous sporulation in B.subtilis 168 was achieved by a step-down procedure, and mutant strains were grown by procedures described previously (Power et al. 1988; Shaker et al. 1988). With strain 168, samples were removed at 30min intervals from t = 0 to t = 12 and at t = 30hr, and exposed to antibacterial agents. Mutant strains were allowed to develop for 20hr 
TI - Development of Biocide Resistance in Bacillus Subtilis 168 and its Sporulation (Spo−) Mutants
JF - Journal of Pharmacy and Pharmacology
DO - 10.1111/j.2042-7158.1990.tb14476.x
DA - 1990-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/development-of-biocide-resistance-in-bacillus-subtilis-168-and-its-CRbH7Nz2zC
SP - 103P
EP - 103P
VL - 42
IS - Supplement_1
DP - DeepDyve
ER -