TY - JOUR
AU - Miller, Paul
AB - of the The MarR Repressor Multiple Antibiotic Resistance in (mar) Operon Escherichia coli: Prototypic Member of a of Family Bacterial Regulatory Proteins Involved in Sensing Phenolic Compounds Mark C. Sulavik, Laura F. Gambino, and Paul F. Miller Infectious Diseases Section, Therapeutics Department, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan, U.S.A. ABSTRACT Background: The marR gene of Escherichia coli encodes repressor activity was identified. database Subsequent a repressor of the marRAB operon, a regulatory locus searching revealed a family of 10 proteins from a variety controlling multiple antibiotic resistance in this organ- of bacteria that share significant amino acid sequence ism. Inactivation of marR results in increased expression similarity to MarR and MprA. At least four of these of marA, which acts at several target genes in the cell proteins are transcriptional repressors whose activity is leading to reduced antibiotic accumulation. Exposure of antagonized by SAL or by phenolic agents structurally E. coli to sodium salicylate (SAL) induces marRAB operon related to SAL. transcription and antibiotic resistance. The Conclusions: mechanism The MarR famnily is identified as a group of by which SAL antagonizes MarR repressor activity is regulatory in re- factors whose activity is modulated unclear. sponse to 
TI - The MarR Repressor of the Multiple Antibiotic Resistance (mar) Operon in Escherichia coli: Prototypic Member of a Family of Bacterial Regulatory Proteins Involved in Sensing Phenolic Compounds
JF - Molecular Medicine
DO - 10.1007/BF03401581
DA - 1995-05-01
UR - https://www.deepdyve.com/lp/springer-journals/the-marr-repressor-of-the-multiple-antibiotic-resistance-mar-operon-in-CvJU9pcy4a
SP - 436
EP - 446
VL - 1
IS - 4
DP - DeepDyve
ER -