TY - JOUR
AU - Doudna, Jennifer A.
AB - GW182-family proteins are essential for microRNA-mediated translational repression and deadenylation in animal cells. Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. Mutations at the complex interface impair mRNA deadenylation in mammalian cell extracts, suggesting that the GW182-PABC interaction contributes to microRNA-mediated gene silencing.
TI - Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation
JF - Nature structural & molecular biology
DO - 10.1038/nsmb.1768
DA - 2010-01-24
UR - https://www.deepdyve.com/lp/pubmed-central/structural-insights-into-the-human-gw182-pabc-interaction-in-microrna-CyQhOAkJHH
SP - 238
EP - 240
VL - 17
IS - 2
DP - DeepDyve
ER -