TY - JOUR
AU1 - Reda, E.
AU2 - D’Iddio, S.
AU3 - Nicolai, R.
AU4 - Benatti, P.
AU5 - Calvani, M.
AB - Carnitine is a trimethylamine molecule that plays a unique
role in cell energy metabolism. Mitochondrial betaoxidation of
long-chain fatty acids, the major process by which fatty acids
are oxidized, is ubiquitously dependent on carnitine. Control of
mitochondrial beta-oxidation through carnitine adapts to
differing requirements in different tissues. The physiological
role of carnitine and its system in body composition is
understood from insights into skeletal muscle metabolism, which
converge into the metabolic heterogeneity of muscle fibers, and
contractile properties that are correlated with phenotypes of
resistance to fatigue. In skeletal muscle, the importance of the
function of the carnitine system in the control and regulation
of fuel partitioning not only relates to the metabolism of fatty
acids and the capacity for fatty acid utilization, but also to
systemic fat balance and insulin resistance. The carnitine
system is shown to be determinant in insulin regulation of fat
and glucose metabolic rate in skeletal muscle, this being
critical in determining body composition and relevant raised
levels of risk factors for cardiovascular disease, obesity,
hypertension, and type 2 diabetes.
TI - The carnitine system and body composition
JF - Acta Diabetologica
DO - 10.1007/s00592-003-0040-z
DA - 2003-10-01
UR - https://www.deepdyve.com/lp/springer-journals/the-carnitine-system-and-body-composition-D4Bijhyopj
SP - s106
EP - s113
VL - 40
IS - 1
DP - DeepDyve
ER -