TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 6, Issue of February 6, pp. 4941–4951, 2004 © 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Structure and Sequence Determinants Required for the RNA Editing of ADAR2 Substrates* Received for publication, September 10, 2003, and in revised form, November 29, 2003 Published, JBC Papers in Press, November 30, 2003, DOI 10.1074/jbc.M310068200 T. Renee Dawson‡, Christopher L. Sansam§, and Ronald B. Emeson‡§ From the Departments of ‡Molecular Physiology and Biophysics and §Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 transcripts (2, 4), yet the basis for their distinct, but overlap- ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian RNAs ping, specificities at particular adenosine moieties is not well by the site-specific conversion of adenosine to inosine. understood (6, 7). The DRBMs of ADAR1 and ADAR2 are We have demonstrated previously that ADAR2 can mod- similar to the domains that mediate dsRNA interactions in a ify its own pre-mRNA, leading to the creation of a prox- large variety of proteins, including dsRNA-dependent protein imal 3
-splice junction containing a non-canonical ade- kinase, Drosophila staufen and Escherichia coli RNase III (8), nosine-inosine 
TI - Structure and Sequence Determinants Required for the RNA Editing of ADAR2 Substrates
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m310068200
DA - 2004-02-01
UR - https://www.deepdyve.com/lp/unpaywall/structure-and-sequence-determinants-required-for-the-rna-editing-of-D7Mvjh0yAR
DP - DeepDyve
ER -