TY - JOUR
AB - HIGHLIGHT S ME TA S TASI S A constricting girdle Keep moving Electrical signalling between nerve and muscle cells is controlled by the acetylcholine (ACh) receptor (AChR) — a transmitter- Tumour-cell metastasis is complex, but the most basic feature is cell gated ion channel. AChR has five subunits (α, α, β, γ or ε, δ), movement — away from the primary tumour through the extracellular which each contain four predicted transmembrane segments matrix (ECM). Cell motility involves remodelling of the cytoskeleton. As (M1–M4). When ACh binds to the ligand-binding regions of the Rho-family GTPases regulate cytoskeletal proteins — through the Rho two α subunits, the cation-selective pore opens. But how does this kinase (ROCK) family — and are often overexpressed in tumours, Sahai and gating occur? In Nature, Unwin and colleagues now provide Marshall studied Rho–ROCK signalling in the motility of tumour-cell lines. insights by describing a 4-Å-resolution model of the closed pore, The ability of some cell lines (such as A375m2 metastatic melanoma) to which was obtained using electron microscopy and crystalline invade a three-dimensional ECM-like matrix was almost completely postsynaptic membranes. blocked by TAT-C3, which inactivates Rho proteins, or Y27632, which The authors found that the pentameric 
TI - Structure Watch
JF - Nature Reviews Molecular Cell Biology
DO - 10.1038/nrm1189
DA - 2003-08-01
UR - https://www.deepdyve.com/lp/springer-journals/structure-watch-DBzDPwuTwZ
SP - 598
EP - 598
VL - 4
IS - 8
DP - DeepDyve
ER -