TY - JOUR
AU - 
AB - G C A T T A C G genes G C A T Review The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects 1 2 1 , Lynh Nguyen , Peter Papenhausen and Haipeng Shao * Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; lynh.nguyen@moffitt.org Cytogenetics Laboratory, Laboratory Corporation of America, Research Triangle Park, NC 27709, USA; papenhp@labcorp.com * Correspondence: haipeng.shao@moffitt.org; Tel.: +1-813-745-2672 Academic Editor: Daitoku Sakamuro Received: 13 January 2017; Accepted: 27 March 2017; Published: 5 April 2017 Abstract: c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-MYC in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, 
TI - The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
JF - Genes
DO - 10.3390/genes8040116
DA - 2017-04-05
UR - https://www.deepdyve.com/lp/unpaywall/the-role-of-c-myc-in-b-cell-lymphomas-diagnostic-and-molecular-aspects-DKud1BZH9P
DP - DeepDyve
ER -