TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272, No. 16, Issue of April 18, pp. 10448 –10456, 1997 © 1997 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3*-Exoribonuclease* (Received for publication, November 26, 1996, and in revised form, February 4, 1997) Christof G. Ko ¨ rner and Elmar Wahle‡ From the Institut fu ¨ r Biochemie, Justus-Liebig-Universita ¨ t, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany and the Department of Cell Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland 3*-Exonucleolytic removal of the poly(A) tail is the lead to altered rates of deadenylation and often to correspond- first and often rate-limiting step in the decay of many ing changes in mRNA half-life (5). Thus, deadenylation is not eucaryotic mRNAs. In a cytoplasmic extract from HeLa only the first step in mRNA decay, but can be rate-limiting cells, the poly(A) tail of mRNA was degraded from the (5, 8). 3*-end. In agreement with earlier in vivo observations, In yeast, poly(A) tail removal requires the cytoplasmic prominent decay intermediates differed in length by poly(A)-binding protein I (PAB I). In strains lacking PAB I, the about 30 nucleotides. The Mg -dependent, poly(A)-spe- 
TI - Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.272.16.10448
DA - 1997-04-01
UR - https://www.deepdyve.com/lp/unpaywall/poly-a-tail-shortening-by-a-mammalian-poly-a-specific-3-DL0h0GQaJA
DP - DeepDyve
ER -