TY - JOUR
AU - Sikela, James M.
AB - Background:  Among some (e.g., DBA/2J or D2) but not all (C57BL/6J or B6) inbred strains of mice, ethanol has a marked psychostimulant effect. Intercrosses formed from the D2 and B6 strains have been used to detect quantitative trait loci (QTLs) for this phenotype. The major QTL is found at the mid‐region of chromosome 2 (Demarest et al., 1999). This QTL has also been detected in heterogeneous stock mice (Demarest et al., 2001). A potential candidate gene in this region is Cas1, which codes for catalase. The current studies were conducted to determine (a) if there was difference in the open reading frame (ORF) of Cas1 between the D2 and B6 strains; (b) if a difference was found, was it likely that the difference had functional effects; and (c) if it could be established that Cas1 meets the criteria for QTL to gene.
TI - Gene Coding Variant in Cas1 Between the C57BL/6J and DBA/2J Inbred Mouse Strains: Linkage to a QTL for Ethanol‐Induced Locomotor Activation
JF - Alcoholism: Clinical & Experimental Research
DO - 10.1111/j.1530-0277.2002.tb02425.x
DA - 2002-01-01
UR - https://www.deepdyve.com/lp/wiley/gene-coding-variant-in-cas1-between-the-c57bl-6j-and-dba-2j-inbred-DRTJdMDnBJ
SP - 1
EP - 7
VL - 26
IS - 1
DP - DeepDyve
ER -