TY - JOUR AU - AB - Downloaded from genesdev.cshlp.org on December 17, 2021 - Published by Cold Spring Harbor Laboratory Press Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer 1,7 1 5 5,6 2,8 Jeroen Charite´, David G. McFadden, Giorgio Merlo, Giovanni Levi, David E. Clouthier, 2,4 3 1,9 Masashi Yanagisawa, James A. Richardson, and Eric N. Olson 1 2 3 4 Department of Molecular Biology, Department of Molecular Genetics, Department of Pathology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75239-9148, USA; Laboratory of Molecular Morphogenesis, National Cancer Institute–I.S.T., 16132 Genova, Italy; Laboratoire de Physiologie, Museum National d’Histoire Naturelle, UMR CNRS 8572, Paris, France Neural crest cells play a key role in craniofacial development. The endothelin family of secreted polypeptides regulates development of several neural crest sublineages, including the branchial arch neural crest. The basic helix–loop–helix transcription factor dHAND is also required for craniofacial development, and in endothelin-1 (ET-1) mutant embryos, dHAND expression in the branchial arches is down-regulated, implicating it as a transcriptional effector of ET-1 action. To determine the mechanism that links ET-1 signaling to dHAND transcription, we analyzed the dHAND gene for cis-regulatory elements that control transcription in the branchial arches. We TI - Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer JF - Genes & Development DO - 10.1101/gad.931701 DA - 2001-11-15 UR - https://www.deepdyve.com/lp/unpaywall/role-of-dlx6-in-regulation-of-an-endothelin-1-dependent-i-dhand-i-DT7wkydWdp DP - DeepDyve ER -