TY - JOUR
AU - Gittis, A G
AB - The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.
TI - Crystal structure of a conserved ribosomal protein-RNA complex.
JF - Science (New York, N.Y.)
DO - 10.1126/science.284.5417.1171
DA - 1999-06-08
UR - https://www.deepdyve.com/lp/pubmed/crystal-structure-of-a-conserved-ribosomal-protein-rna-complex-DU0V06m8Y0
SP - 1171
EP - 4
VL - 284
IS - 5417
DP - DeepDyve
ER -