TY - JOUR AU - Gittis, A G AB - The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome. TI - Crystal structure of a conserved ribosomal protein-RNA complex. JF - Science (New York, N.Y.) DO - 10.1126/science.284.5417.1171 DA - 1999-06-08 UR - https://www.deepdyve.com/lp/pubmed/crystal-structure-of-a-conserved-ribosomal-protein-rna-complex-DU0V06m8Y0 SP - 1171 EP - 4 VL - 284 IS - 5417 DP - DeepDyve ER -