TY - JOUR
AU - Tang, Daolin
AB - Curr Pathobiol Rep (2017) 5:153–159 DOI 10.1007/s40139-017-0139-5 AUTOPHAGY IN PATHOBIOLOGY (W-X DING AND H-M SHEN, SECTION EDITORS) 1 1,2 Rui Kang & Daolin Tang Published online: 20 April 2017 Springer Science+Business Media New York 2017 . . . Abstract Keywords Ferroptosis Autophagy Signal transduction . . Purpose of Review Autophagy is a conserved intracellular Molecular interaction Lipid peroxidation Iron metabolism degradation system and plays a dual role in cell death, depend- ing on context and phase. Ferroptosis is a new form of regu- lated cell death that mainly depends on iron accumulation and Abbreviations lipid peroxidation. In this review, we summarize the processes RCD Regulated cell death of autophagy and ferroptosis and discuss their crosstalk mech- ATG Autophagy-regulated anisms at the molecular level. TEM Transmission electron microscopy Recent Findings The original study shows that ferroptosis is RSL RAS-selective lethal morphologically, biochemically, and genetically distinct from RIPK Receptor interacting serine/threonine kinase autophagy and other types of cell death. However, recent stud- ROS Reactiveoxygenspecies ies demonstrate that activation of ferroptosis is indeed depen- NCOA4 Nuclear receptor coactivator 4 dent on the induction of autophagy. Additionally, many GSH Glutathione ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, SLC7A11 Solute carrier family 7 
TI - Autophagy and Ferroptosis—What Is the Connection?
JF - Current Pathobiology Reports
DO - 10.1007/s40139-017-0139-5
DA - 2017-04-20
UR - https://www.deepdyve.com/lp/springer-journals/autophagy-and-ferroptosis-what-is-the-connection-Dn0RMyy32b
SP - 153
EP - 159
VL - 5
IS - 2
DP - DeepDyve
ER -